Annals of Tropical Pathology

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2011| June | Volume 2 | Issue 1
Online since December 27, 2017

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ORIGINAL ARTICLES

Morphological patterns of prostatic lesions in Benin City, Nigeria: A twenty year retrospective study
G Forae, DE Obaseki, JU Aligbe, VJ Ekanem
June 2011, 2(1):23-28

[ABSTRACT] Full text not available [PDF]

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Antiretroviral therapy and haemostatic parameters in HIV patients with haemoglobin phenotypes AS and AA
AO Adebayo, OA Awodu, AA Famodu
June 2011, 2(1):15-21

Background: Haematological and coagulation defects have been reported in advanced HIV infection, the occurrence of the S gene is high in African Blacks. HIV infection is on the increase in Nigeria. About a quarter of Nigerians have haemoglobin phenotype HbAS. The haemostatic parameters have not been fully determined in Nigerians with haemoglobin HbAS Aims: To determine the effects of HIV infection on haematological and haemostatic profiles of Nigerians with the sickle cell trait : haemoglobin As(HbAS) and haemoglobin AA(HbAA) Methods: Subjects comprised of phenotype HBAS and HB AA patients who were newly diagnosed with HIV infection and those already on antiretroviral therapy(ART). Control group comprised of apparently healthy subjects with haemoglobin phenotypes AS and AA. Blood samples were analysed for haematological parameters :(haematocrit(Hct), total white cell count (WCC), platelet count(Plt)) and Haemostatic parameters: (plasma fibrinogen concentration(Pfc), prothrombin time(PT) and Activated partial thromboplastin time(APTT) . All analyses were carried out using standard techniques. Quantitative assay was conducted to estimate D-dimer levels. Results: A total of 145 subjects were studied. The mean haemoglobin(Hb), and WCC were higher in HBAS than HbAA subjects with HIV infection but the differences in the mean values were not Statistically significant(p>0.5). The PT, APTT and the Pfc were significantly more prolonged in HBAS with HIV infection than in Hb AS controls (p<0.0001). The haemostatic parameters were also significantly more prolonged in HBAA with HIV than HbAA HIV negative controls (p<0.0001). Elevation of D-dimer was found in 12 and 20% of HbAS and HbAA HIV positive subjects respectively. Positive D-dimer was found to be significantly associated with HIVinfection (p = 0.0007) in both HbAS and HbAA subjects. Conclusion: This study has shown that Hb phenotype does not influence the effect of HIV infection on haemostatic and haematological parameters. Elevated plasma fibrinogen concentration, prolongation of APTT and presence of D-dimer, in HIV infection may suggest an inflammatory response as well as subclinical coagulapathy

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Susceptibility profile of clinical isolates of Pseudomonas aeruginosa to recommended antipseudomonal antibiotics in Ibadan, Nigeria
AO Okesola, AA Oni
June 2011, 2(1):37-43

[ABSTRACT] Full text not available [PDF]

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Relationship between microalbuminuria and dyslipidaemia in type - 2 diabetes mellitus patients
BE Kasia, ES Idogun
June 2011, 2(1):29-35

Background: It is widely reported that dyslipidaemia is a common feature of type 2 diabetes mellitus and is often associated with a higher risk of diabetic complications. Objectives: Lipid profile and microalbuminuria were examined in all type 2 diabetes mellitus patients. The prevalence of dyslipidaemia was determined and comparison was made amongst the normotensive and hypertensive diabetic patients presenting with microalbuminuria and normotensive diabetes without microalbuminuria. Patients and methods: Ninety- five (95) type 2 diabetes mellitus patients and 20 healthy controls were randomly selected and studied. Seventeen (17) of them were normotensive diabetics with microalbuminuria, forty (40) were hypertensive diabetics with microalbuminuria and thirty-eight (38) were normotensive diabetics without microalbuminuria. The weight, height and blood pressure of the patients were measured and their blood and urine samples were obtained for plasma lipid profile and albumin-creatinine ratio respectively. Results: The mean total cholesterol and low density lipoprotein cholesterol was highest in normotensive DM presenting with microalbuminuria 5.4(1.87) mmol/l and 3.74(1.71) mmol/l, compared to hypertensive DM with microalbuminuria 5.28(1.38)mmol/l and 3.67(1.33)mmol/l and lowest in the normotensive DM without microalbuminuria 5.1(1.32)mmol/l and 3.36(1.15)mmol/l p<0.05. A high proportion of diabetic patients presenting with microalbuminuria (normotensive (65%) and hypertensive (67%) had high total cholesterol, this was similar to the diabetics without microalbuminuria (63%) whereas a lower proportion (30% ) of the control(non diabetics) has high TC value p=0.0001. Similarly high proportions of the DM patients 47%,57% and 50% respectively had high low density lipoprotein values compared to controls(non-diabetics) (30%) p=0.0012. Conclusion: These findings draw specific attention to the need to screening for microalbuminuria in patients with dyslipidaemia as this will reduce the risk or slow down the progress of cardiovascular complications.

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REVIEW

Recent advances in stem cell biology: Implications for tropical haematology practice
Anthony A Oyekunle
June 2011, 2(1):7-14

[ABSTRACT] Full text not available [PDF]

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LETTER TO THE EDITOR

Sudden death from ruptured berry aneurysms in a 55 year-old man
M Nnoli, I Chukwuonye, O Kanu, C Nnoli
June 2011, 2(1):45-46

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EDITORIAL

Ethics in Publishing: Keeping an Eye on Propriety
Olusegun Ojo
June 2011, 2(1):5-6

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OBITUARY AND TRIBUTE

Tribute to Dr. Mobolaji Olufemi Dada, 1962-2010 Consultant Haematologist
Taofeek K Owonikoko
June 2011, 2(1):47-48

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