RT - Journal TY - JOUR A1 - Okocha, E A1 - Ejele, O A1 - Ibeh, C A1 - Aneke, J T1 - Prevalence of Hepatitis B surface Antigen (HBsAg) seropositivity in sickle cell anaemia patients in Benin City, Mid-Western Nigeria YR - 2013/12/1 JF - Annals of Tropical Pathology JO - Ann Trop Pathol SP - 25 OP - 29 VO - 4 IS - 2 UL - https://www.atpjournal.org/article.asp?issn=2251-0060;year=2013;volume=4;issue=2;spage=25;epage=29;aulast=Okocha;t=5 N2 - Background: Conditions that may require regular blood transfusion are particularly prone to acquiring transfusion transmissible infections. Objective: To determine the prevalence of HBsAg seropositivity among sickle cell anaemia (SCA) patients. Subjects and Methods: Ninety-six (SCA) patients age range 1–69 years, and 92 age-matched controls were screened for exposure to Hepatitis B virus (HBV) using, solid base wet ELISA test kits (Monolisa® from Sanofi diagnostics). All the participants were further stratified into those with a prior history of transfusion and those without, the prevalence of HBsAg was compared in the two groups. Results: The prevalence rate of HBsAg was 29.2% in SCA patients, while it was 27.2% in the controls. The difference was not statistically significant (P>0.05). The overall risk of HBV infection in SCA patients was not clearly increased by blood transfusion, even though the Relative risk (1.4%), compared to that of the control population (1.2%) and Attributable risk (8.4%), compared to that of the control population (6.6%) were increased. Conclusion: Transmission of hepatitis B virus infection from blood transfusion does not appear to contribute significantly to the high prevalence of seropositivity in our population of SCA patients. Universal vaccination of these subjects against hepatitis B virus is advocated as a way to possibly reduce this prevalence. ER -